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Cell. 2010 Jan 8;140(1):30-2. doi: 10.1016/j.cell.2009.12.038.

MicroTUB(B3)ules and brain development.

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1
Howard Hughes Medical Institute, Cambridge, MA 02139, USA.

Abstract

The microtubule network is crucial for the developing nervous system, and mutations in tubulin-encoding genes disrupt neuronal migration. Tischfield et al. (2010) now report that mutations in the tubulin-encoding gene TUBB3 have a striking impact on microtubule dynamics in neurons, resulting in a diverse set of disease symptoms.

PMID:
20085703
DOI:
10.1016/j.cell.2009.12.038
[Indexed for MEDLINE]
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