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Cancer Causes Control. 2010 May;21(5):719-27. doi: 10.1007/s10552-009-9500-2. Epub 2010 Jan 19.

Maternal hormones during early pregnancy: a cross-sectional study.

Author information

1
Division of Cancer Epidemiology, German Cancer Research Center, In Neuenheimer Feld 280, Heidelberg, Germany.

Abstract

BACKGROUND:

Little is known about correlates of first-trimester pregnancy hormones as in most studies maternal hormones have been measured later in gestation. We examined the associations of maternal characteristics and child sex with first-trimester maternal concentrations of four hormones implicated in breast cancer: human chorionic gonadotropin (hCG), alpha-fetoprotein (AFP), insulin-like growth factor (IGF)-I, and IGF-II.

METHODS:

About 338 serum samples donated to the Northern Sweden Maternity Cohort (NSMC), 1975-2001, during the first trimester of uncomplicated pregnancies, were analyzed for the hormones of interest as a part of a case-control study. The associations of maternal characteristics and child sex with hormone concentrations were investigated by correlation, general linear regression, and multivariate regression models.

RESULTS:

In the first trimester, greater maternal age was inversely correlated with IGF-I and IGF-II. In comparison with women carrying their first child, already parous women had higher IGF-I but lower hCG. Greater maternal weight and smoking were inversely correlated with hCG. No differences in hormone levels by child sex were observed.

CONCLUSIONS:

Our analyses indicated that potentially modifiable maternal characteristics (maternal weight and smoking) influence first-trimester pregnancy maternal hormone concentrations.

PMID:
20084544
PMCID:
PMC2880501
DOI:
10.1007/s10552-009-9500-2
[Indexed for MEDLINE]
Free PMC Article
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