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Prion. 2010 Jan-Mar;4(1):26-31. Epub 2010 Jan 4.

Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins.

Author information

1
Department of Biotechnology, Graduate School of Engineering, Tokyo University of Agriculture & Technology, Koganei-shi, Tokyo, Japan.

Abstract

Several neurodegenerative diseases involve the selective damage of neuron cells resulting from the accumulation of amyloid fibril formation. Considering that the formation of amyloid fibrils as well as their precursor oligomers is cytotoxic, the agents that prevent the formation of oligomers and/or fibrils might allow the development of a novel therapeutic approach to neurodegenerative diseases. Here, we show pyrroloquinoline quinone (PQQ) inhibits the amyloid fibril formation of the amyloid proteins, amyloid beta (1-42) and mouse prion protein. The fibril formation of mouse prion protein in the presence of PQQ was dramatically prevented. Similarly, the fibril formation of amyloid beta (1-42) also decreased. With further advanced pharmacological approaches, PQQ may become a leading anti-neurodegenerative compound in the treatment of neurodegenerative diseases.

PMID:
20083898
PMCID:
PMC2850417
DOI:
10.4161/pri.4.1.10889
[Indexed for MEDLINE]
Free PMC Article

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