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Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S162-6. doi: 10.1016/S1353-8020(09)70806-5.

Is the loss of thalamostriatal neurons protective in parkinsonism?

Author information

1
Program in Neuroscience and Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA.

Abstract

Neuronal loss in Parkinson's disease (PD) is more widespread than originally thought. Among the extrastriatal sites in which significant loss of neurons has been reported is the centremedian-parafascicular (CM-PF) complex of the thalamus, which provides one of the three major afferent sources to the striatum. The functional significance of CM-PF loss in PD is unclear. Interestingly, several recent small trials have suggested that deep brain stimulation of the CM-PF improves motor function in PD. We discuss the possible transsynaptic determination of CM-PF loss secondary to nigrostriatal dopamine degeneration, and suggest that expression of the glycoprotein cerebellin1 (Cbln1) in CM-PF neurons may play an important role in striatal synaptic remodeling in parkinsonism.

PMID:
20082981
PMCID:
PMC2900831
DOI:
10.1016/S1353-8020(09)70806-5
[Indexed for MEDLINE]
Free PMC Article

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