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Clin Dermatol. 2010 Jan-Feb;28(1):62-6. doi: 10.1016/j.clindermatol.2009.04.004.

What is really in control of skin immunity: lymphocytes, dendritic cells, or keratinocytes? facts and controversies.

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Department of Dermatology and Allergology, Ludwig-Maximilian-University, 80337 Munich, Germany.


The pathophysiology of atopic dermatitis is still under discussion. Although it is widely accepted that environmental factors and a genetic predisposition are essential, the role of the innate and adaptive immune system and the functional cascade of the cells involved is still unclear. A concept that integrates all immune cells as equally essential has allure. In addition, barrier abnormalities due to mutations of the gene coding for filaggrin and down-regulation of antimicrobial peptides, such as LL-37 and beta-defensins 2 and 3, were very recently found to be relevant for the pathogenesis of atopic dermatitis.

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