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Int J Legal Med. 2011 Jan;125(1):143-7. doi: 10.1007/s00414-009-0404-1. Epub 2010 Jan 15.

Software for Y-haplogroup predictions: a word of caution.

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  • 1Laboratorio de Genética Molecular Poblacional, Instituto Multidisciplinario de Biología Celular (IMBICE), CICPBA, CCT, La Plata-CONICET, Argentina.


The development of online software designed for genetic studies has been exponentially growing, providing numerous benefits to the scientific community. However, they should be used with care, since some require adjustments. The efficiency of two programs for haplogroup prediction was tested with 119 samples of known haplotypes and haplogroups from Argentine populations. Quantitative estimates of the predictive quality of both software systems were computed with the uncertainty coefficient; and sensitivity, specificity, positive, and negative likelihood ratios were also calculated to assert the reliability of both programs, showing high probabilities of assigning an incorrect haplogroup.

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