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Nat Chem Biol. 2010 Mar;6(3):202-204. Epub 2010 Jan 17.

Carbon metabolism-mediated myogenic differentiation.

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[1] Vascular Biology Program, Department of Pathology and Department of Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] These authors contributed equally to this work.


The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered that the knockdown of three metabolic enzymes-phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl)-induces differentiation of mouse C2C12 myoblasts even in the presence of mitogens. These enzymes and the pathways they regulate provide new targets for the control of myogenic differentiation in myoblasts and rhabdomyosarcoma cells.

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