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FEBS Lett. 2010 May 17;584(10):2043-8. doi: 10.1016/j.febslet.2010.01.013. Epub 2010 Jan 16.

Mitochondrial potassium channels and reactive oxygen species.

Author information

1
Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, 3 Pasteur st., 02-093 Warsaw, Poland.

Abstract

Pretreatment of tissues with potassium channel openers (KCO's) has been observed to be cytoprotective in a broad variety of insults. This phenomenon has been proposed to be intimately linked to activation of mitochondrial potassium channels which apparently modulate the mitochondrial production of reactive oxygen species (ROS). This critical review summarizes literature findings about the mitochondrial production of ROS, the action of KCO's on mitochondrial ROS production and the putative link to the cytoprotective action of these drugs.

PMID:
20080090
DOI:
10.1016/j.febslet.2010.01.013
[Indexed for MEDLINE]
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