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Bioorg Med Chem Lett. 2010 Feb 15;20(4):1399-404. doi: 10.1016/j.bmcl.2009.12.107. Epub 2010 Jan 4.

Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators.

Author information

1
Department of Medicinal Chemistry, Laboratoire GlaxoSmithKline, Centre de Recherches, 25-27 Avenue du Qu├ębec, 91951 Les Ulis, France. yann.lamotte@gsk.com

Abstract

Starting from the structure of Telmisartan, a new series of potent and selective PPARgamma modulators was identified. The synthesis, in vitro and in vivo evaluation of the most potent compounds are reported and the X-ray structure of compound 7b bound to the PPARgamma ligand binding domain is described.

PMID:
20079636
DOI:
10.1016/j.bmcl.2009.12.107
[Indexed for MEDLINE]

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