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Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):337-51. doi: 10.1016/j.bbagrm.2010.01.004. Epub 2010 Jan 14.

RNA silencing directed against geminiviruses: post-transcriptional and epigenetic components.

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1
Department of Molecular Genetics and Plant Biotechnology Center, and the Graduate Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, Columbus, OH 43210, USA.

Abstract

It is well-established that plants use cytoplasmic, post-transcriptional gene silencing (PTGS) as a defense against RNA viruses and DNA virus transcripts. More recently, it has become clear that small RNA-directed methylation leading to transcriptional gene silencing (TGS) is also used as a defense against DNA virus chromatin. Here we use the DNA-containing geminiviruses as models to discuss what is currently known about both types of antiviral silencing, and viral suppression of PTGS and TGS as a counterdefense.

PMID:
20079472
DOI:
10.1016/j.bbagrm.2010.01.004
[Indexed for MEDLINE]
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