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FEBS Lett. 2010 Apr 2;584(7):1342-9. doi: 10.1016/j.febslet.2010.01.006. Epub 2010 Jan 13.

Autophagy takes flight in Drosophila.

Author information

1
University of Minnesota, Department of Genetics, Cell Biology, and Development, Minneapolis, MN 55455, USA. chang220@umn.edu

Abstract

Drosophila has been shown to be a powerful model to study autophagy, whose regulation involves a core machinery consisting of Atg proteins and upstream signaling regulators similar to those in yeast and mammals. The conserved role in degrading proteins and organelles gives autophagy an important function in coordinating several cellular processes as well as in a number of pathological conditions. This review summarizes key studies in Drosophila autophagy research and discusses potential questions that may lead to better understanding of the roles and regulation of autophagy in higher eukaryotes.

PMID:
20079355
PMCID:
PMC2843783
DOI:
10.1016/j.febslet.2010.01.006
[Indexed for MEDLINE]
Free PMC Article

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