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Exp Neurol. 2010 May;223(1):45-50. doi: 10.1016/j.expneurol.2009.12.032. Epub 2010 Jan 14.

PTEN/mTOR and axon regeneration.

Author information

1
F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. kevin.park@childrens.harvard.edu

Abstract

How axon regeneration is controlled in both PNS and CNS remains elusive. Mechanistic studies of axon growth during development and axon regeneration after injury reveal the PTEN dependent molecular mechanism as a commonality. This pathway could impact the processes occurring in the neuronal soma, such as mTOR-regulated protein translation, and in the axons, such as cytoskeleton assembly. In this review, we will discuss the current understanding of the involvement of these processes in the regulation of axon growth and the potential implication in promoting axon regeneration after injury.

PMID:
20079353
DOI:
10.1016/j.expneurol.2009.12.032
[Indexed for MEDLINE]

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