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Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009 Dec;31(6):782-5. doi: 10.3881/j.issn.1000-503X.2009.06.027.

[Research advances in Sirt1 gene].

[Article in Chinese]

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  • 1National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Beijing 100005, China.


As the most homologic homologue of silent information regulator 2 of yeast, Sirt1 gene is extensively expressed in mature tissues, and is rich in early embryo and reproductive cells. It is involved in the regulation of gene transcription, energy metabolism and cell aging. It promotes fat mobilization in adipocytes and glucose production in liver and regulates insulin secretion in islet beta cell. Furthermore, Sirt1 gene is an essential endogenous apoptosis inhibitor. In future, it may be used as new drug targets or applied in other disease management modalities.

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