Send to

Choose Destination
See comment in PubMed Commons below
J Clin Neurol. 2009 Dec;5(4):173-7. doi: 10.3988/jcn.2009.5.4.173. Epub 2009 Dec 31.

Validity and Reliability of the Greek Version of the Multiple Sclerosis International Quality-of-Life Questionnaire.

Author information

Department of Neurology, University of Athens, Athens, Greece.



There are no data regarding psychometrically validated, health-related quality-of-life instruments designed specifically for patients with multiple sclerosis (MS) in Greece. Recently, the MS International Quality-of-Life questionnaire (MusiQoL), a multidimensional, self-administered questionnaire, which is available in 14 languages (including Greek), has been validated using a large international sample. We investigated the validity and reliability of the Greek version of the MusiQoL.


Consecutive patients with different types and severities of MS were recruited from two tertiary-care centers in Greece. All patients completed the MusiQoL, the Short-Form-36 quality-of-life questionnaire (SF-36), and a symptom checklist at baseline and 21+/-7 days (mean+/-SD) later. Data regarding sociodemographic status, MS history, and functional outcome were also collected prospectively. Construct validity, internal consistency, reproducibility, and external consistency were tested.


A total of 92 patients was evaluated. The construct validity was confirmed in terms of satisfactory item-internal consistency correlations and scaling success (87.5-100%) of item-discriminant validity. The dimensions of the MusiQoL exhibited high internal consistency (Cronbach's alpha: 0.63-0.96), and reproducibility was satisfactory (intraclass correlation coefficients: 0.69-0.99). External validity testing indicated that the MusiQoL correlated significantly with all SF-36 dimension scores (Spearman's correlation: 0.43-0.76).


The Greek version of the MusiQoL appears to be a valid and reliable instrument for measuring quality of life in Greek MS patients.


Greece; epilepsy; quality of life; questionnaire

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Korean Neurological Association Icon for PubMed Central
    Loading ...
    Support Center