Format

Send to

Choose Destination
Curr Opin Neurobiol. 2010 Feb;20(1):79-85. doi: 10.1016/j.conb.2009.12.006. Epub 2010 Jan 14.

Axon guidance at the midline: of mice and flies.

Author information

1
Department of Neuroscience, University of Pennsylvania School of Medicine, 421 Curie Boulevard, BRB2/3 1113, Philadelphia, PA 19104, USA.

Abstract

In bilaterally symmetric organisms, the midline is a critical organizing center for the developing central nervous system. There is a striking conservation of the molecules and mechanisms that control axon path finding at the midline in vertebrate and invertebrate nervous systems. The majority of axons in the CNS cross the midline before projecting to their contralateral synaptic targets and this crossing decision is under exquisite spatial and temporal regulation. Growing commissural axons initially respond to attractive signals, while inhibiting responses to repulsive signals. Once across, repulsion dominates, allowing axons to leave and preventing them from re-entering the midline. Here we review recent advances in flies and mice that illuminate the molecular mechanisms underlying the establishment of precise connectivity at the midline.

PMID:
20074930
PMCID:
PMC4128228
DOI:
10.1016/j.conb.2009.12.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center