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FEBS Lett. 2010 Apr 2;584(7):1302-12. doi: 10.1016/j.febslet.2010.01.011. Epub 2010 Jan 13.

Regulation of autophagy by phosphatidylinositol 3-phosphate.

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1
Signalling Programme, Babraham Institute, Cambridge, UK.

Abstract

The simple phosphoinositide phosphatidylinositol 3-phosphate (PI(3)P) has been known to have important functions in endocytic and phagocytic traffic, and to be required for the autophagic pathway. In all of these settings, PI(3)P appears to create platforms that serve to recruit specific effectors for membrane trafficking events. In autophagy, PI(3)P may form the platform for autophagosome biogenesis.

PMID:
20074568
DOI:
10.1016/j.febslet.2010.01.011
[Indexed for MEDLINE]
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