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Biochem Soc Trans. 2010 Feb;38(Pt 1):104-9. doi: 10.1042/BST0380104.

Control of PCNA deubiquitylation in yeast.

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1
Instituto de Biología Molecular y Celular del Cáncer, Campus Miguel de Unamuno, Universidad de Salamanca/CSIC, 37007 Salamanca, Spain.

Abstract

Eukaryotes ubiquitylate the replication factor PCNA (proliferating-cell nuclear antigen) so that it tolerates DNA damage. Although, in the last few years, the understanding of the evolutionarily conserved mechanism of ubiquitylation of PCNA, and its crucial role in DNA damage tolerance, has progressed impressively, little is known about the deubiquitylation of this sliding clamp in most organisms. In the present review, we will discuss potential molecular mechanisms regulating PCNA deubiquitylation in yeast.

PMID:
20074044
DOI:
10.1042/BST0380104
[Indexed for MEDLINE]
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