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Curr Opin Pulm Med. 2010 Mar;16(2):123-33. doi: 10.1097/MCP.0b013e328336438d.

Structural and functional changes of peripheral muscles in chronic obstructive pulmonary disease patients.

Author information

1
ELEGI Laboratory, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK. roberto.rabinovich@ed.ac.uk

Abstract

PURPOSE OF REVIEW:

The purpose of this review is to identify new advances in our understanding of skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD).

RECENT FINDINGS:

Recent studies have confirmed the relevance of muscle dysfunction as an independent prognosis factor in COPD. Animal studies have shed light on the molecular mechanisms governing skeletal muscle hypertrophy/atrophy. Recent evidence in patients with COPD highlighted the contribution of protein breakdown and mitochondrial dysfunction as pathogenic mechanisms leading to muscle dysfunction in these patients.

SUMMARY:

COPD is a debilitating disease impacting negatively on health status and the functional capacity of patients. COPD goes beyond the lungs and incurs significant systemic effects among which muscle dysfunction/wasting is one of the most important. Muscle dysfunction is a prominent contributor to exercise limitation, healthcare utilization and an independent predictor of morbidity and mortality. Gaining more insight into the molecular mechanisms leading to muscle dysfunction/wasting is key for the development of new and tailored therapeutic strategies to tackle skeletal muscle dysfunction/wasting in COPD patients.

PMID:
20071991
PMCID:
PMC2920417
DOI:
10.1097/MCP.0b013e328336438d
[Indexed for MEDLINE]
Free PMC Article

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