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J Atten Disord. 2011 Jan;15(1):79-91. doi: 10.1177/1087054709356173. Epub 2010 Jan 13.

Effect of micronutrients on behavior and mood in adults With ADHD: evidence from an 8-week open label trial with natural extension.

Author information

1
Department of Psychology, University of Canterbury, Christchurch, New Zealand. julia.rucklidge@canterbury.ac.nz

Abstract

OBJECTIVE:

To investigate the effect of a 36-ingredient micronutrient formula consisting mainly of minerals and vitamins in the treatment of adults with both ADHD and severe mood dysregulation (SMD).

METHOD:

14 medication-free adults (9 men, 5 women; 18-55 years) with ADHD and SMD completed an 8-week open-label trial.

RESULTS:

A minority reported transitory mild side effects. Significant improvements were noted across informants (self, observer, clinician) on measures of inattention and hyperactivity/impulsivity, mood, quality of life, anxiety, and stress all with medium to very large effect sizes (all ps < .01); however, the mean of inattention remained in a clinical range whereas the means on measures of mood and hyperactivity/impulsivity were normalized. Follow-up data showed maintenance of changes or further improvement for those who stayed on the micronutrients.

CONCLUSIONS:

Although this study, as an open trial, does not in itself prove efficacy, it provides preliminary evidence supporting the need for a randomized clinical trial of micronutrients as treatment for the more complex presentations of ADHD.

PMID:
20071638
DOI:
10.1177/1087054709356173
[Indexed for MEDLINE]

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