Format

Send to

Choose Destination
Schizophr Res. 2010 Jun;119(1-3):75-8. doi: 10.1016/j.schres.2009.12.021. Epub 2010 Jan 13.

Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis.

Author information

1
Department of Psychological Medicine, Institute of Psychiatry, King's College London, London, UK. valeria.mondelli@kcl.ac.uk

Abstract

This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion.

PMID:
20071148
PMCID:
PMC3513409
DOI:
10.1016/j.schres.2009.12.021
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center