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Euro Surveill. 2009 Dec 17;14(50). pii: 19446.

First human case of Usutu virus neuroinvasive infection, Italy, August-September 2009.

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Department of Diagnostic and Laboratory Services and Legal Medicine, University of Modena and Reggio Emilia, Azienda Ospedaliera Policlinico, Modena, Italy.


We report the first worldwide case of Usutu virus (USUV) neuroinvasive infection in a patient with diffuse large B cell lymphoma who presented with fever and neurological symptoms and was diagnosed with meningoencephalitits. The cerebrospinal fluid was positive for USUV, and USUV was also demonstrated in serum and plasma samples by RT-PCR and sequencing. Partial sequences of the premembrane and NS5 regions of the viral genome were similar to the USUV Vienna and Budapest isolates.

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