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J Bioenerg Biomembr. 2010 Feb;42(1):29-35. doi: 10.1007/s10863-009-9263-1. Epub 2010 Jan 13.

Coupling factor B affects the morphology of mitochondria.

Author information

1
West Los Angeles Veterans Administration Medical Center, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA. gbelo@ucla.edu

Abstract

Ectopic expression of coupling factor B in animal cells resulted in altered mitochondrial morphology. Cells expressing factor B fused to green fluorescent protein (GFP) contained fragmented, balloon-shaped or thinned, filamentous mitochondria, terminating at one end with balloon-like structures. Ultrastructural analysis using transmission electron microscopy revealed changes in the organization of mitochondrial cristae in cells expressing factor B-GFP fusion protein.

PMID:
20069349
PMCID:
PMC2843765
DOI:
10.1007/s10863-009-9263-1
[Indexed for MEDLINE]
Free PMC Article

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