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Nat Rev Mol Cell Biol. 2010 Feb;11(2):91-102. doi: 10.1038/nrm2832. Epub 2010 Jan 13.

Mechanisms of chromosome behaviour during mitosis.

Author information

1
Medical Sciences Program, Indiana University, Myers Hall 262, 915 East 3rd Street, Bloomington, Indiana, 47405, USA. cwalczak@indiana.edu

Abstract

For over a century, scientists have strived to understand the mechanisms that govern the accurate segregation of chromosomes during mitosis. The most intriguing feature of this process, which is particularly prominent in higher eukaryotes, is the complex behaviour exhibited by the chromosomes. This behaviour is based on specific and highly regulated interactions between the chromosomes and spindle microtubules. Recent discoveries, enabled by high-resolution imaging combined with the various genetic, molecular, cell biological and chemical tools, support the idea that establishing and controlling the dynamic interaction between chromosomes and microtubules is a major factor in genomic fidelity.

PMID:
20068571
PMCID:
PMC2893392
DOI:
10.1038/nrm2832
[Indexed for MEDLINE]
Free PMC Article

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