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Kidney Blood Press Res. 2009;32(6):457-63. doi: 10.1159/000274046.

Increased risk of chronic kidney disease in elderly with metabolic syndrome and high levels of C-reactive protein: Kahrizak Elderly Study.

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Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.



To explore the interrelationship between metabolic syndrome (MS), chronic kidney disease (CKD) and C-reactive protein (CRP) in an elderly Iranian cohort.


122 residents of Kahrizak Charity Foundation aged >or= 60 years were enrolled in this survey. MS was defined according to the NCEP-ATPIII criteria. CKD was defined as an estimated glomerular filtration rate < 60 ml/min/1.73 m2. CRP levels >or= 3 mg/dl were determined as a high CRP.


The multivariate-adjusted odds ratio (OR) for CKD in MS was 5.81 (95% confidence interval (CI) 1.72-19.58) compared to those without MS. High blood pressure and high triglyceride levels were significantly associated with an increased risk of CKD (OR 4.01, 95% CI 1.55-10.37 and OR 3.27, 95% CI 1.25-8.53, respectively). Subjects with MS and high CRP levels had a 1.71-fold greater risk of having CKD compared to those without MS and low CRP levels (95% CI 1.02-2.84).


There was a strong and independent relation between MS and risk of CKD in these elderly people. High blood pressure and hypertriglyceridemia increased the risk of CKD. Combination of high CRP and MS was strongly associated with an increased risk of CKD.

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