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J Biol. 2009;8(11):96. doi: 10.1186/jbiol207. Epub 2009 Dec 23.

Chromatin 'programming' by sequence--is there more to the nucleosome code than %GC?

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1
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street No, 903, Worcester, MA 01605, USA.

Abstract

The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can largely be captured with a simple model, and in fact is mostly explained by %GC. Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed. See research article http://www.biomedcentral.com/1471-2105/10/442.

PMID:
20067596
PMCID:
PMC2804288
DOI:
10.1186/jbiol207
[Indexed for MEDLINE]
Free PMC Article
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