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Am J Psychiatry. 1991 Apr;148(4):484-8.

Relation of CSF neurotensin concentrations to symptoms and drug response of psychotic patients.

Author information

1
Department of Psychiatry and Behavioral Neurobiology, School of Medicine, University of Alabama, Birmingham 35294.

Abstract

OBJECTIVE:

The authors investigated the putative endogenous antipsychotic neurotensin in relation to both psychotic symptoms and patterns of response during treatment with an antipsychotic drug.

METHOD:

Twenty recently admitted patients with mood-incongruent psychoses underwent 1) interviews with the Schedule for Affective Disorders and Schizophrenia for diagnostic evaluation and symptom profiles, 2) drug-free baseline measurements of CSF neurotensin and homovanillic acid, and 3) close monitoring of a therapeutic trial of haloperidol to determine latency of antipsychotic response.

RESULTS:

A relative deficiency in CSF neurotensin was found in a subgroup of psychotic women whose clinical response to haloperidol was delayed for 11 to 35 days after initiation of the neuroleptic. These patients had greater thought disorder, delusions-hallucinations, behavioral disorganization, and impaired functioning than did psychotic patients with higher CSF concentrations of neurotensin. Neurotensin concentrations increased during treatment with haloperidol.

CONCLUSIONS:

The study provides further evidence that there is diminished availability of neurotensin in some psychotic patients, with increases in neurotensin early in neuroleptic treatment. Exploration of neurotensin receptor agonists as a potentially novel class of antipsychotic compounds is suggested.

PMID:
2006695
DOI:
10.1176/ajp.148.4.484
[Indexed for MEDLINE]

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