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Cold Spring Harb Perspect Biol. 2009 Nov;1(5):a002998. doi: 10.1101/cshperspect.a002998.

Molecular bases of cell-cell junctions stability and dynamics.

Author information

1
IBDML, UMR CNRS-Université de la Méditerranée, Marseille, France.

Abstract

Epithelial cell-cell junctions are formed by apical adherens junctions (AJs), which are composed of cadherin adhesion molecules interacting in a dynamic way with the cortical actin cytoskeleton. Regulation of cell-cell junction stability and dynamics is crucial to maintain tissue integrity and allow tissue remodeling throughout development. Actin filament turnover and organization are tightly controlled together with myosin-II activity to produce mechanical forces that drive the assembly, maintenance, and remodeling of AJs. In this review, we will discuss these three distinct stages in the lifespan of cell-cell junctions, using several developmental contexts, which illustrate how mechanical forces are generated and transmitted at junctions, and how they impact on the integrity and the remodeling of cell-cell junctions.

PMID:
20066121
PMCID:
PMC2773640
DOI:
10.1101/cshperspect.a002998
[Indexed for MEDLINE]
Free PMC Article

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