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Arch Neurol. 2010 Jan;67(1):122-5. doi: 10.1001/archneurol.2009.298.

The stripe of primary lateral sclerosis: focal primary motor cortex hypometabolism seen on fluorodeoxyglucose F18 positron emission tomography.

Author information

1
Departments of Neurology, Mayo Clinic and Mayo College of Medicine, Rochester, Minnesota 55905, USA.

Abstract

BACKGROUND:

Primary lateral sclerosis (PLS) is a progressive upper motor neuron neurodegenerative condition. The diagnosis is made using clinical history, objective neurological assessment, and exclusion of other neurodegenerative disorders.

OBJECTIVE:

To evaluate the role of fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection in the diagnosis of PLS.

DESIGN:

Case series.

SETTING:

Outpatient neurology clinic. Patients Three cases of probable PLS. Intervention Fluorodeoxyglucose F18 positron emission tomography in 3 patients with PLS.

RESULTS:

Three patients (2 male and 1 female; mean age, 65 years) were identified with a clinical diagnosis of PLS. Fluorodeoxyglucose F18 positron emission tomography demonstrated varying degrees of primary motor cortex hypometabolism.

CONCLUSION:

Fluorodeoxyglucose F18 positron emission tomography and 3-dimensional stereotactic surface projection provide a useful diagnostic method to support a clinical diagnosis of PLS.

PMID:
20065142
DOI:
10.1001/archneurol.2009.298
[Indexed for MEDLINE]

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