Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Neurol. 2010 Jan;67(1):87-92. doi: 10.1001/archneurol.2009.308.

Association of C-reactive protein with cognitive impairment.

Author information

1
Gertrude H Sergievsky Center, Columbia University, New York, New York, USA

Abstract

BACKGROUND:

High-sensitivity C-reactive protein (hsCRP) is a biomarker of cardiovascular risk that is suggested to be a biomarker for cognitive impairment.

OBJECTIVE:

To explore the association between hsCRP and cognitive impairment.

DESIGN:

Cross-sectional analysis of a population-based community aging study.

SETTING:

Northern Manhattan, New York, New York.

OTHER PARTICIPANTS:

One thousand three hundred thirty-one participants from a longitudinal study of aging without dementia and with available hsCRP and neuropsychological testing data at baseline.

MAIN OUTCOME MEASURES:

Four cognitive scores (memory, visuospatial, executive, and language impairment) derived from a neuropsychological battery. Cognitive impairment was defined by scores below 1.5 SDs of demographically corrected means.

RESULTS:

Participants in the highest hsCRP tertile had higher adjusted odds of impaired memory (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.0-2.1; P = .03) than participants in the lowest tertile. Subjects in the highest hsCRP tertile also had greater odds of visuospatial impairment (OR, 1.6; 95% CI, 1.0-2.3; P = .03). Higher hsCRP was not associated with executive or language impairment. Persons with at least 1 APOE epsilon4 allele and hsCRP in the highest tertile had the greatest odds of impaired memory (OR, 2.7; 95% CI, 1.6-4.4).

CONCLUSIONS:

High hsCRP may be a marker of memory and visuospatial impairment in the elderly. The role of APOE epsilon4 requires further exploration.

PMID:
20065134
PMCID:
PMC4426905
DOI:
10.1001/archneurol.2009.308
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Support Center