Format

Send to

Choose Destination
Antimicrob Agents Chemother. 2010 Mar;54(3):1338-42. doi: 10.1128/AAC.01197-09. Epub 2010 Jan 11.

Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates.

Author information

1
Division of Infectious Diseases, National Health Research Institutes, 35 Keyan Rd. Zhunan, Taiwan 350. lauderdale@nhri.org.tw

Abstract

The in vitro antibacterial activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, against 770 clinical isolates were investigated. Nemonoxacin (tested as its malate salt, TG-875649) showed better in vitro activity than ciprofloxacin and levofloxacin against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenzae. The in vitro activity of TG-875649 was also comparable to or better than that of moxifloxacin against these pathogens, which included ciprofloxacin-resistant, methicillin-resistant Staphylococcus aureus and levofloxacin-resistant Streptococcus pneumoniae.

PMID:
20065058
PMCID:
PMC2825994
DOI:
10.1128/AAC.01197-09
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center