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Am J Trop Med Hyg. 2010 Jan;82(1):45-8. doi: 10.4269/ajtmh.2010.08-0626.

Familial analysis of seropositivity to Trypanosoma cruzi and of clinical forms of Chagas disease.

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1
Disciplina de Genética, Federal University of the Triângulo Mineiro, Uberaba, Minas Gerais, Brazil. rlope@terra.com.br

Abstract

A cross-sectional study was carried out in Agua Comprida, MG, Brazil, a region previously endemic to Chagas disease whose vectorial transmission was interrupted around 20 year ago. A total of 998 individuals were examined for anti-Trypanosoma cruzi antibodies. Seropositivity was observed in 255 subjects (25.5%), and 743 subjects were negative. Forty-one families with 5-80 individuals with similar environmental conditions were selected for familial analysis. In 15 families, seropositivity to T. cruzi was observed in > 50% of individuals. The segregation analysis confirmed family aggregation for the seropositivity to the T. cruzi. Heart commitment was the major clinical form observed, and in six families, > 50% of the individuals display cardiopathy that may be attributed to T. cruzi infection. Our results support the hypothesis that there is a family aggregation for the seropositivity but without the effect of one major gene.

PMID:
20064994
PMCID:
PMC2803508
DOI:
10.4269/ajtmh.2010.08-0626
[Indexed for MEDLINE]
Free PMC Article
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