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Mol Cell. 2009 Dec 25;36(6):932-41. doi: 10.1016/j.molcel.2009.11.020.

Eukaryotic stress granules: the ins and outs of translation.

Author information

1
Howard Hughes Medical Institute, University of Arizona, Tucson, 85721, USA.

Abstract

The stress response in eukaryotic cells often inhibits translation initiation and leads to the formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress granules contain nontranslating mRNAs, translation initiation components, and many additional proteins affecting mRNA function. Stress granules have been proposed to affect mRNA translation and stability and have been linked to apoptosis and nuclear processes. Stress granules also interact with P-bodies, another cytoplasmic RNP granule containing nontranslating mRNA, translation repressors, and some mRNA degradation machinery. Together, stress granules and P-bodies reveal a dynamic cycle of distinct biochemical and compartmentalized mRNPs in the cytosol, with implications for the control of mRNA function.

PMID:
20064460
PMCID:
PMC2813218
DOI:
10.1016/j.molcel.2009.11.020
[Indexed for MEDLINE]
Free PMC Article

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