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Mol Cell. 2009 Dec 25;36(6):924-31. doi: 10.1016/j.molcel.2009.12.011.

Shifting players and paradigms in cell-specific transcription.

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1
Howard Hughes Medical Institute, University of California, Berkeley, 94720, USA.

Abstract

Historically, developmental-stage- and tissue-specific patterns of gene expression were assumed to be determined primarily by DNA regulatory sequences and their associated activators, while the general transcription machinery including core promoter recognition complexes, coactivators, and chromatin modifiers was held to be invariant. New evidence suggests that significant changes in these general transcription factors including TFIID, BAF, and Mediator may facilitate global changes in cell-type-specific transcription.

PMID:
20064459
PMCID:
PMC2807468
DOI:
10.1016/j.molcel.2009.12.011
[Indexed for MEDLINE]
Free PMC Article
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