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Chem Biol. 2009 Dec 24;16(12):1216-8. doi: 10.1016/j.chembiol.2009.12.003.

Targeting multiple biofilm pathways.

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1
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

Cegelski et al. (2009) demonstrate the importance of amyloid production for biofilm formation and host colonization using several mutant strains of pathogenic E. coli and small molecule inhibitors. This work reveals a path forward for studying the role of bacterial amyloids in vivo and suggests the potential for small molecules to target multiple biofilm formation pathways.

PMID:
20064430
DOI:
10.1016/j.chembiol.2009.12.003
[Indexed for MEDLINE]
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