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BMC Infect Dis. 2010 Jan 12;10:7. doi: 10.1186/1471-2334-10-7.

Evidence for a "Founder Effect" among HIV-infected injection drug users (IDUs) in Pakistan.

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1
Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.

Abstract

BACKGROUND:

We have previously reported a HIV-1 subtype A infection in a community of injection drug users (IDUs) in Karachi, Pakistan. We now show that this infection among the IDUs may have originated from a single source.

METHODS:

Phylogenetic analysis was performed of partial gag sequences, generated using PCR, from 26 HIV-positive IDU samples.

RESULTS:

Our results showed formation of a tight monophyletic group with an intra-sequence identity of < 98% indicating a "founder effect". Our data indicate that the HIV-1 epidemic in this community of IDUs may have been transmitted by an HIV positive overseas contract worker who admitted to having contact with commercial sex workers during stay abroad.

CONCLUSION:

Specific measures need to implemented to control transmission of HIV infection in Pakistan through infected migrant workers.

PMID:
20064274
PMCID:
PMC2820481
DOI:
10.1186/1471-2334-10-7
[Indexed for MEDLINE]
Free PMC Article
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