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Neuropsychology. 2010 Jan;24(1):77-83. doi: 10.1037/a0015046.

Response variability is associated with self-reported cognitive fatigue in multiple sclerosis.

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Department of Psychology, University of Missouri-Kansas City, 5100 Rockhill Road, Kansas City, MO 64110, USA.


Cognitive fatigue is a common, often debilitating symptom of multiple sclerosis (MS). Although MS patients frequently report that fatigue negatively affects cognitive functioning, most studies have found little evidence for a direct relationship between self-reported cognitive fatigue and traditional measures of neuropsychological functioning. The purpose of the present study was to examine the association between self-reported cognitive fatigue and a measure of response time variability (RTV). MS patients demonstrated significantly higher RTV than controls, and RTV was highly correlated with self-reported cognitive fatigue among relapsing-remitting and secondary progressive MS patients. Results highlight the need to implement newer methods to further elucidate the relationship between cognitive fatigue and neuropsychological functioning in MS.

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