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Brief Bioinform. 2010 Jan;11(1):15-29. doi: 10.1093/bib/bbp057. Epub 2010 Jan 8.

Toward the dynamic interactome: it's about time.

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1
National Center of Biotechnology Information, NLM, NIH, 8000 Rockville Pike, Bethesda MD 20814, USA. przytyck@ncbi.nlm.nih.gov

Abstract

Dynamic molecular interactions play a central role in regulating the functioning of cells and organisms. The availability of experimentally determined large-scale cellular networks, along with other high-throughput experimental data sets that provide snapshots of biological systems at different times and conditions, is increasingly helpful in elucidating interaction dynamics. Here we review the beginnings of a new subfield within computational biology, one focused on the global inference and analysis of the dynamic interactome. This burgeoning research area, which entails a shift from static to dynamic network analysis, promises to be a major step forward in our ability to model and reason about cellular function and behavior.

PMID:
20061351
PMCID:
PMC2810115
DOI:
10.1093/bib/bbp057
[Indexed for MEDLINE]
Free PMC Article
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