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Dev Biol. 2010 Mar 15;339(2):366-73. doi: 10.1016/j.ydbio.2009.12.041. Epub 2010 Jan 6.

NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division.

Author information

1
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Ji.Liu@umassmed.edu

Abstract

The nonmuscle myosin II NMY-2 is required for cytokinesis as well as for the establishment of zygote asymmetry during embryogenesis in Caenorhabditis elegans. Here we describe two conditional nmy-2 alleles that rapidly and reversibly inactivate the protein. We show that NMY-2 has late-cell-cycle roles in maintaining embryonic asymmetries and is also required for a surprisingly late step in the maintenance of the cytokinesis furrow. Finally, during a signaling-induced asymmetric cell division, NMY-2 is required for SRC-dependent phosphotyrosine signaling and acts in parallel with WNT-signaling to specify endoderm.

PMID:
20059995
PMCID:
PMC2903000
DOI:
10.1016/j.ydbio.2009.12.041
[Indexed for MEDLINE]
Free PMC Article

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