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Dev Cell. 2009 Dec;17(6):752-4. doi: 10.1016/j.devcel.2009.12.003.

TTC3 ubiquitination terminates Akt-ivation.

Author information

1
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. atoker@bidmc.harvard.edu

Abstract

In this issue of Developmental Cell, Suizu et al. (2009) describe a new mechanism for posttranslational regulation of the Akt serine/threonine protein kinase involving ubiquitination. They show that the E3 ubiquitin ligase TTC3 modifies phosphorylated and activated Akt and thereby promotes its degradation by the proteasome in the nucleus.

PMID:
20059946
DOI:
10.1016/j.devcel.2009.12.003
[Indexed for MEDLINE]
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