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Dev Cell. 2009 Dec;17(6):750-2. doi: 10.1016/j.devcel.2009.12.002.

Outsmarting a mastermind.

Author information

1
Regulatory Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037-1099, USA. jones@salk.edu

Abstract

Moellering et al. recently reported that a cell-permeable "stapled" synthetic peptide of the Notch coactivator Mastermind is a potent dominant-negative inhibitor of oncogenic Notch signaling in T cell acute lymphoblastic leukemia. This new class of inhibitor may find broad utility in blocking protein-protein interactions that underlie many human diseases.

PMID:
20059945
PMCID:
PMC2810139
DOI:
10.1016/j.devcel.2009.12.002
[Indexed for MEDLINE]
Free PMC Article

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