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Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):1-8. doi: 10.1158/1055-9965.EPI-08-1111.

Prostate cancer risk allele specific for African descent associates with pathologic stage at prostatectomy.

Author information

1
Urology Service, Department of Surgery, Walter Reed Army Medical Center, Washington, District of Columbia, USA.

Erratum in

  • Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):890. Sestrehenn, Isabell A [corrected to Sesterhenn, Isabell A].

Abstract

PURPOSE:

A region on chromosome 8q24 was recently identified as a novel prostate cancer risk locus. Inherited variation in this region is associated with prostate cancer risk in the general population (21-58%), and specific alleles show a strong association in African-American men. This study was designed to evaluate associations between 8q24 risk alleles and clinical variables, such as pathologic stage, age at diagnosis, and recurrence, in a case series of African-American men.

EXPERIMENTAL DESIGN:

Peripheral blood DNA samples from 114 African-American men with prostate cancer, including 106 who had undergone radical prostatectomy, were genotyped for six single-nucleotide polymorphisms on three 8q24 regions. The presence of these single-nucleotide polymorphisms was compared with clinicopathologic and follow-up data after radical prostatectomy.

RESULTS:

The mean age of diagnosis and follow-up time were 57.4 (+/-8.9) years and 49.1 (+/-31.6) months, respectively. Patients carrying the Broad11934905 A risk allele, which is specific for African ancestry, were more likely to have a higher pathologic stage (pT(3-4)) than individuals with the wild type (odds ratio, 4.48; 95% confidence interval, 1.42-14.14; P = 0.011). A trend toward increased frequency of and shorter time to biochemical recurrence was noted in patients with this risk allele on Kaplan-Meier unadjusted survival analysis (P = 0.076).

CONCLUSIONS:

The Broad11934905 polymorphism at 8q24, which is only found in people of African ancestry, is associated with an increase in non-organ-confined prostate cancer at prostatectomy. In addition, for those with this risk allele, there is a trend toward early biochemical recurrence that requires validation in larger studies.

PMID:
20056617
DOI:
10.1158/1055-9965.EPI-08-1111
[Indexed for MEDLINE]
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