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Fertil Steril. 2010 Aug;94(3):1138-40. doi: 10.1016/j.fertnstert.2009.11.030. Epub 2010 Jan 8.

The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study.

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  • 1Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California, USA.


Compared with placebo, alendronate treatment resulted in a significant protection against bone loss in healthy perimenopausal women. This protection occurred at both the spine and the hip and was evident after 6 months of therapy.

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