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Med Mycol. 2010 Feb;48(1):197-200. doi: 10.3109/13693780902717018.

Acquired resistance to voriconazole and itraconazole in a patient with pulmonary aspergilloma.

Author information

1
Laboratoire de Parasitologie-Mycologie, CHU de Saint Etienne, Hôpital Nord, Saint Etienne, France.

Abstract

We describe the development of resistance in an Aspergillus fumigatus strain, originally sensitive to itraconazole and voriconazole, recovered from a case of pulmonary aspergilloma treated with voriconazole. A G448S mutation on the cyp51A gene was detected by sequencing. Frequent culture and in vitro antifungal susceptibility testing is suggested for early detection of the development of multi-azole resistance in patients on long-term therapy for A. fumigatus infections.

PMID:
20055745
DOI:
10.3109/13693780902717018
[Indexed for MEDLINE]

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