Format

Send to

Choose Destination
Expert Opin Ther Targets. 2010 Feb;14(2):179-92. doi: 10.1517/14728220903544507.

TGF-beta signalling and immunity in prostate tumourigenesis.

Author information

1
Hanson Institute, Experimental Therapeutics Laboratory, Adelaide, SA 5000, Australia.

Abstract

IMPORTANCE OF THE FIELD:

The TGF-beta's are pleiotropic cytokines that regulate multiple cellular functions. Their role in the prostate is important for normal prostate development and also in prostate tumourigenesis.

AREAS COVERED IN THIS REVIEW:

The interactions TGF-beta-mediated signalling has with maintaining prostate health, as well as its role in prostate tumourigenesis and prostate tumour immune evasion, with emphasis on how a breakdown in these interactions may influence disease progression.

WHAT THE READER WILL GAIN:

That TGF-beta influences normal prostate growth and differentiation by regulating the balance between epithelial cell proliferation and apoptosis, and involving the androgen receptor pathway. That TGF-beta protects and maintains prostate stem cells and a review of the contrasting role TGF-beta has in prostate tumourigenesis and tumour development, where TGF-beta acts as a tumour suppressor and then switches roles to become a tumour promoter, and creates a local immunosuppressive niche leading to systemic tumour tolerance.

TAKE HOME MESSAGE:

TGF-beta signalling in prostate cancer is a valid target for the treatment of this disease; however any therapeutic regimen will require an understanding of all aspects of the TGF-beta-signalling nexus, otherwise by the very pleiotrophic nature of TGF-beta, limited clinical benefits may result.

PMID:
20055717
DOI:
10.1517/14728220903544507
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center