Format

Send to

Choose Destination
Hippocampus. 2010 Aug;20(8):902-5. doi: 10.1002/hipo.20743.

Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers.

Author information

1
Department of Biology, The University of Texas at San Antonio, One UTSA circle, San Antonio, Texas 78249, USA.

Abstract

Changes in brain cholesterol homeostasis are associated with multiple diseases, such as Alzheimer's and Huntington's; however, controversy persists as to whether adult neurons produce their own cholesterol, or if it is outsourced to astrocytes. To address this issue, we analyzed 25 genes most immediately involved in cholesterol homeostasis from in situ data provided by the Allen Brain Mouse Atlas. We compared the relative mRNA expression in the pyramidal and granule layers, populated with neurons, with the rest of the hippocampus which is populated with neuronal processes and glia. Comparing the expression of the individual genes to markers for neurons and astrocytes, we found that cholesterol homeostasis genes are preferentially targeted to neuronal layers. Therefore, changes in gene expression levels might affect neuronal populations directly.

PMID:
20054815
PMCID:
PMC2889181
DOI:
10.1002/hipo.20743
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center