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Korean J Physiol Pharmacol. 2009 Dec;13(6):431-6. doi: 10.4196/kjpp.2009.13.6.431. Epub 2009 Dec 31.

Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase.

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1
Department of Physiology, School of Medicine, Chungnam National University, Daejeon 301-131, Korea.

Abstract

The role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the lead (Pb)-induced cellular response was investigated in the cultured endothelial cells. Pb caused progressive cellular death in endothelial cells, which occurred in a concentration- and time-dependent manner. However, Ref-1 overexpression with AdRef-1 significantly inhibited Pb-induced cell death in the endothelial cells. Also the overexpression of Ref-1 significantly suppressed Pb-induced superoxide and hydrogen peroxide elevation in the endothelial cells. Pb exposure induced the downregulation of catalase, it was inhibited by the Ref-1 overexpression in the endothelial cells. Taken together, our data suggests that the overexpression of Ref-1 inhibited Pb-induced cell death via the upregulation of catalase in the cultured endothelial cells.

KEYWORDS:

Apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1); Catalase; Cell death; Endothelial cells; Lead

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