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Int J Mol Sci. 2009 Dec 21;10(12):5471-84. doi: 10.3390/ijms10125471.

Immune response among patients exposed to molds.

Author information

1
Allergy/Immunology Department at Ear, Nose and Throat Associates of North Central Wisconsin, 2801 Westhill Dr., Wausau, WI 54401, USA. dedmondson@westernu.edu

Abstract

Macrocyclic trichothecenes, mycotoxins produced by Stachybotrys chartarum, have been implicated in adverse reactions in individuals exposed to mold-contaminated environments. Cellular and humoral immune responses and the presence of trichothecenes were evaluated in patients with mold-related health complaints. Patients underwent history, physical examination, skin prick/puncture tests with mold extracts, immunological evaluations and their sera were analyzed for trichothecenes. T-cell proliferation, macrocyclic trichothecenes, and mold specific IgG and IgA levels were not significantly different than controls; however 70% of the patients had positive skin tests to molds. Thus, IgE mediated or other non-immune mechanisms could be the cause of their symptoms.

KEYWORDS:

clinical symptoms; immune response; molds; mycotoxins

PMID:
20054481
PMCID:
PMC2802005
DOI:
10.3390/ijms10125471
[Indexed for MEDLINE]
Free PMC Article
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