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J Biol. 2009;8(12):104. doi: 10.1186/jbiol190. Epub 2009 Dec 29.

Scribble at the crossroads.

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1
Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, 25 rue du Dr Roux, 75724 Paris cedex 15, France. sandrine.etienne-manneville@pasteur.fr

Abstract

Although proteins involved in determining apical-basal cell polarity have been directly linked to tumorigenesis, their precise roles in this process remain unclear. A recent report in BMC Biology clarifies the signaling pathways that control cell polarity, proliferation and apoptosis downstream of the tumor suppressor and apical-basal polarity determinant Scribble.

PMID:
20053305
PMCID:
PMC2804276
DOI:
10.1186/jbiol190
[Indexed for MEDLINE]
Free PMC Article
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