Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Invest. 2010 Jan;120(1):11-9. doi: 10.1172/JCI40373.

Repairing skeletal muscle: regenerative potential of skeletal muscle stem cells.

Author information

1
Division of Regenerative Medicine, San Raffaele Scientific Institute, 58 via Olgettina, Milan, Italy.

Abstract

Skeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between the basal lamina and the muscle fiber membrane. However, other cell types outside the basal lamina, such as pericytes, also have myogenic potency. Here, we discuss the main properties of satellite cells and other myogenic progenitors as well as recent efforts to obtain myogenic cells from pluripotent stem cells for patient-tailored cell therapy. Clinical trials utilizing these cells to treat muscular dystrophies, heart failure, and stress urinary incontinence are also briefly outlined.

PMID:
20051632
PMCID:
PMC2798695
DOI:
10.1172/JCI40373
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Society for Clinical Investigation Icon for PubMed Central
    Loading ...
    Support Center