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Biomarkers. 2010 Feb;15(1):20-30. doi: 10.3109/13547500903186452.

Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC.

Author information

1
Columbia University Mailman School of Public Health, New York, NY, USA.

Abstract

The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by (32)P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 micromol GSH g(-1) haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.

PMID:
20050820
PMCID:
PMC3696993
DOI:
10.3109/13547500903186452
[Indexed for MEDLINE]
Free PMC Article

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